Preparation of rat model of systemic inflammatory response syndrome induced by zymosan / 浙江大学学报·医学版

<p><b>OBJECTIVE</b>To establish a model of systemic inflammatory response syndrome (SIRS) in rats.</p><p><b>METHODS</b>SD rats were intraperitoneally injected with different concentrations of zymosan suspension. The general status, temperature, white cell count, tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-10 (IL-10) and the pathological changes of main organs were examined.</p><p><b>RESULTS</b>The conditions of rats receiving zymosan doses of 750 mg/kg and 1000 mg/kg were consistent with the criteria of SIRS model; however, the mortality of 1000 mg/kg group was higher than that of 750 mg/kg group.</p><p><b>CONCLUSION</b>The rat model of systemic inflammatory response syndrome has been successfully induced.</p>